It will be much easier if you use CP2102, FT232RL, or CH340. Usually ESP32 boards have CP2102 chips. https://www.theengineeringprojects.com/2020/12/esp32-pinout-datasheet-features-applications.html Yes, I know and have used those before. But the XR chip has particular advantages in my current scena...

I would like to ask, has anyone ever used XR21V1410 to make the USB connection with a PICO-V3 and implemented the automatic programming with it? I am considering this chip for my board, but am concerned whether its default configuration (automatic RTS/manual DTR) will work to control the EN and IO0 ...