After more checking, I found that my SPI_CS0 PIN (32) is high (3.3V) when the board is plugged in.
Checking my Fash datasheet, the CS pin is active low; I'm not sure if ESP32 will manage that internally, pulling it low when required, or if it should be low at all times.

Hi ESP_Sprite,
Thanks for checking the Schematic.
I am only using the CP2102 3.3 output for the RX and TX LEDs are connected to the same chip. The rest of the circuit uses a MIC5216-3.3YM5-TR for power, which is rated at 500MA.

Thanks.
Alex

Hi Everyone, Thanks for your time; I appreciate any help to guide me in the right direction. I have designed a custom PCB with ESP32-S3 and CP2102N-Axx-xQFN24 as the UDB to UART bridge. The design includes an external SPI FLASH, which I'm using W25Q128JVSIQ in this case. The COM port is detected wit...