> The first are two out of four JTAG signals, the second are serial signals. Thank you for the clarification. I checked again and now detected that TX0 RX0 are with GPIO43 44 while MTDO MTDI are with GPIO40 41. So this will indeed not be the way forward for me. My development/debug environment is VS...

Sorry, I am totally new to this topic and I most probably mix something up, here. So MTDO and MTDI are not equal with RX0 TX0 ? There is this other picture in the documentation ( see attached ) And this Register-bit USB_JTAG_BRIDGE_ENABLE in Register USB_SERIAL_JTAG_CONF0_REG (0x0018) looks to me as...

My PCB holds two ESP32-S3: schematics like shown on picture attached. EN, BOOT, Rx0 and TX0 are connected. EN resets both SoCs when powering up. But there is only one USB connection on this PCB, which is conneced to the first SoC. I can upload firmware and debug this first SoC - this works just fine...