Thanks for you help, I was able to burn the efuse with a different computer. I guess one of the drivers I am using with VisualGDB was preventing the esp32 from being recognized as a serial device.

Unfortunately the port either doesn't show up or I get one of the following errors: c:/Espressif/frameworks/esp-idf-v4.4.2/components/esptool_py/esptool/espefuse.py --port COM8 burn_efuse STRAP_JTAG_SEL 1 Connecting...................................... A fatal error occurred: Failed to connect to E...

Hi I am working on a custom board using the esp32s3. The project is highly space constrained and as a result there is no room to provide a connection to the uart0 pins. Is there a way to burn efuses using just the usb-jtag or is espefuse.py only compatible with UART?